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Zvi Laron, MD; Beatrice Klinger, MD; Michael Grunebaum, MD; Murray Feingold, MD; Walter W. Tunnessen, MD

Am J Dis Child. 1991;145(4):473-474.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Denouement and Discussion

Laron-Type Dwarfism

Manifestations

Laron-type dwarfism is characterized by marked growth retardation, acromicria (small hands, feet, and chin), obesity, and micropenis. Craniofacial abnormalities include a protruding forehead, saddle nose, and an increased biparietal-bicondylar ratio, all caused by marked underdevelopment of the facial bones. Head circumference is decreased, skeletal maturation is markedly retarded, the bones are very thin, and there is an increased incidence of minor skeletal abnormalities such as slipped femoral epiphyses and Legg-Calve-Perthes disease. The obesity is generalized and there is underdevelopment of muscle mass. Genitalia and gonads are small, and . . . [Full Text PDF of this Article]

Author Affiliations
Contributed from the Institute of Pediatric and Adolescent Endocrinology (Drs Laron and Klinger) and Department of Pediatric Roentgenology (Dr Grunebaum), Beilinson Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv (Israel) University.

Footnotes
Accepted for publication December 12, 1990.

Reprint requests to National Birth Defects Center, Franciscan Children's Hospital, 30 Warren St, Brighton, MA 02135 (Dr Feingold).

The Editors welcome contributions to Picture of the Month and Radiological Case of the Month. Those who wish to contribute should send their manuscripts to Dr Tunnessen (Picture of the Month), The Children's Hospital of Philadelphia, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, or Dr Wood (Radiological Case of the Month), Department of Radiology, Childrens Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027. Articles and photographs accepted for publication will bear the contributor's name. There is no charge for reproduction and printing of color illustrations.

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