This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Nutritional and Metabolic Disorders  • Nutritional and Metabolic Disorders, Other  • Pediatrics, Other  • Endocrine Diseases  • Diabetes Mellitus  • Alert me on articles by topic  Social Bookmarking   What's this?

Gia Oh, MD; Steve Anderson, PhD; Daniel Tancredi, PhD; Nathan Kuppermann, MD, MPH; Nicole Glaser, MD

Arch Pediatr Adolesc Med. 2009;163(8):771-772.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Hyperglycemia osmotically draws water into the vascular space, decreasing serum sodium concentration. In 1973, Katz¹ theorized that sodium concentration should decrease by 1.6 mmol/L for every 100-mg/dL increase in serum glucose concentration (to convert serum glucose to millimoles per liter, multiply by 0.0555). More recent calculations suggest coefficients ranging from 1.35 to 2.0.^2-3 A study in adults found empirical values ranging from 2.4 to 4.0,⁴ contrasting with theoretical estimates. We empirically determined the sodium correction factor for hyperglycemia using data from children with diabetic ketoacidosis.

Methods

We recorded data—including serum glucose, sodium, and triglyceride concentrations; urine volume and sodium concentrations; and volume and sodium concentration of intravenous fluids administered—from children enrolled in a larger study of diabetic ketoacidosis. During the first 3 hours of treatment, patients were frequently in transport or treated in referring hospitals, . . . [Full Text of this Article]

Results

Comment

AUTHOR INFORMATION


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?