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Universal Primer Polymerase Chain Reaction Looks Promising for Newborns With Low Pretest Probability of Sepsis—Reply
Lisa Ross DeCamp, MD, MSPH;
Amanda F. Dempsey, MD, PhD, MS;
Beth A. Tarini, MD, MS
Arch Pediatr Adolesc Med. 2009;163(7):676.
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In reply
Drs Newman and Kohn believe that our conclusion that universal PCR is not accurate enough to withhold antibiotic therapy in neonates undergoing evaluation for sepsis is too pessimistic. Specifically, they contend that universal PCR might prove useful in the normal newborn nursery, where studies have shown the risk of sepsis in asymptomatic infants to be as low as 1%.1
Using test characteristics from Dutta et al,2 Drs Newman and Kohn demonstrate how a negative universal PCR result in an asymptomatic full-term infant translates into a posttest sepsis risk of 1 in 2500. They conclude that such a low risk of sepsis could change treatment in these newborns from empirical antibiotic therapy while awaiting blood culture results to observation without antibiotics. Their conclusion is based on the principle that "whether the result of . . . [Full Text of this Article] AUTHOR INFORMATION
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Diagnosis of Neonatal Sepsis Using Universal Primer Polymerase Chain Reaction Before and After Starting Antibiotic Drug Therapy
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RELATED LETTER
Universal Primer Polymerase Chain Reaction Looks Promising for Newborns With Low Pretest Probability of Sepsis
Thomas B. Newman and Michael A. Kohn
Arch Pediatr Adolesc Med. 2009;163(7):675-676.
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