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Henrique Nascimento, Licentiate; Letíicia Silva; Pedro Lourenço; Emíilia Vieira, MA; Rosário dos Santos, MD; Carla Rego, MD; Helena Ferreira, MD; Alexandre Quintanilha, PhD; Alice Santos-Silva, PhD; Luíis Belo, PhD

Arch Pediatr Adolesc Med. 2009;163(4):393-394.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Lipoprotein(a) (Lp[a]) levels are known to be mainly genetically determined. A pentanucleotide repeat polymorphism, (TTTTA)n, 1.4 kilobases upstream from the gene reading frame has been studied as a possible influence in Lp(a) levels.¹ To date, repeat sequences ranging from 5 to 12 have been found, with the 8-repeat sequence the most common. Alleles containing more repeats are usually associated with lower Lp(a) levels. The influence of the pentanucleotide repeat on Lp(a) seems to be independent from other polymorphisms.^1-2 To our knowledge, this is the first study to assess the influence of this polymorphism in an obese pediatric population.

In this study, we hypothesized that the pentanucleotide repeat polymorphism influenced the Lp(a) levels in obese Portuguese children and adolescents and that the . . . [Full Text of this Article]

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