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Propensity Scores
Peter Cummings, MD, MPH
Arch Pediatr Adolesc Med. 2008;162(8):734-737.
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In this issue of Archives, Rozé and colleagues1 report results from a cohort study of premature infants receiving mechanical ventilation after birth. Among infants treated with prolonged sedation or analgesia, 41 of 97 (42%) had later disability compared with 324 of 1248 (26%) other infants (crude [unadjusted] risk ratio, 1.6; 95% confidence interval, 1.3-2.1). The treated infants had characteristics that might cause disability, such as younger gestational age and more malformations at birth. Should the harmful association between treatment and disability be attributed to the treatment, the characteristics of those who received the treatment, both, or neither?
CONFOUNDING
When the causal effects of a treatment are entwined with other factors that may have causal effects, we call this confounding.2-4 A clinical trial with random allocation to treatment can minimize confounding by measured and unmeasured factors, because random allocation will, on average, create treated and control groups . . . [Full Text of this Article]
PROPENSITY SCORES
OTHER USES OF PROPENSITY SCORES
CAUTIONS
CASE-CONTROL STUDIES
OUTCOME SCORES
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AUTHOR INFORMATION
RELATED ARTICLE
Prolonged Sedation and/or Analgesia and 5-Year Neurodevelopment Outcome in Very Preterm Infants: Results From the EPIPAGE Cohort
Jean-Christophe Rozé, Sophie Denizot, Ricardo Carbajal, Pierre-Yves Ancel, Monique Kaminski, Catherine Arnaud, Patrick Truffert, Stéphane Marret, Jaqueline Matis, Gérard Thiriez, Gilles Cambonie, Monique André, Béatrice Larroque, and Gérard Bréart
Arch Pediatr Adolesc Med. 2008;162(8):728-733.
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