This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Dermatology  • Pediatrics, Other  • Picture of the Month  • Dermatologic Disorders, Other  • Hematology/ Hematologic Malignancies  • Leukemias/ Lymphomas  • Alert me on articles by topic

Arch Pediatr Adolesc Med. 2006;160:1178-1179.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Denouement and Discussion: Anaplastic Large Cell Lymphoma With Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) may occur in a primary form, often associated with mutations in the perforin gene responsible for natural killer cell cytotoxic activity,¹ or secondary to underlying rheumatic disease (most commonly systemic-onset juvenile rheumatoid arthritis), infection (usually herpesvirus infections such as Epstein-Barr virus or virtually any bacteria, fungus, or parasite), immunodeficiency (Griscelli syndrome), lysinuric protein intolerance, and malignancies. Lymphomas are the most common malignancies associated with HLH, and although HLH is frequently associated with subcutaneous T-cell lymphomas,² it is exceedingly rare as part of anaplastic large cell lymphoma (ALCL), as was observed in this case.³

Lymphomas, including Hodgkin and non-Hodgkin (NHL), account for 10% to 15% of childhood cancer in developed countries, and ALCL accounts for 10% of NHL in childhood. Anaplastic large cell lymphoma is a mature T-cell or null-cell lymphoma that has been recognized as a distinct entity in the classification of NHL.⁴ The 2 subtypes of . . . [Full Text of this Article]

CLINICAL MANIFESTATIONS

DIAGNOSIS

TREATMENT

AUTHOR INFORMATION

RELATED ARTICLE

Picture of the Month—Quiz Case
Jon M. Burnham, Portia A. Kreiger, Michele Paessler, Leslie S. Kersun, and Randy Q. Cron
Arch Pediatr Adolesc Med. 2006;160(11):1177.
EXTRACT | FULL TEXT