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Mineral Metabolism and Calcitriol Therapy in Idiopathic Juvenile Osteoporosis
Giuseppe Saggese, MD;
Silvano Bertelloni, MD;
Giampiero I. Baroncelli, MD;
Giuseppe Perri, MD;
Andrea Calderazzi, MD
Am J Dis Child. 1991;145(4):457-462.
Abstract
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• Idiopathic juvenile osteoporosis is a rare cause of osteoporosis during childhood. We examined four children (three boys and one girl, ranging in age from 2.3 to 12.6 years) with idiopathic juvenile osteoporosis. All of these patients had normal serum calcium, ionized calcium, phosphate, magnesium, 25-hydroxyvitamin D, intact parathyroid hormone, and total and extractable calcitonin levels. 1,25-Dihydroxyvitamin D values were low in three patients and slightly decreased in one. Three children were treated with calcitriol (1,25 - dihydroxycholecalciferol) (0.50 µg/d in two and 0.25 µg/d in the other). The fourth patient was not treated because of parental refusal. Therapy reduced the fracture rate. Follow-up at 6 and 12 months showed a significant increase in bone mineralization, which reached normal values in two children after 12 months of treatment. No side effects of calcitriol therapy were observed. The untreated patient did not show an improvement of bone mineralization in the same time.
(AJDC. 1991;145:457-462)
Author Affiliations
From the Vitamin D Laboratory and Calcium Research Center, Endocrine Unit, Department of Pediatrics (Drs Saggese, Bertelloni, and Baroncelli), and Institute of Radiology (Drs Perri and Calderazzi), University of Pisa, Italy.
Footnotes
Accepted for publication August 23, 1990.
Reprint requests to Vitamin D Laboratory and Calcium Research Center, Endocrine Unit, Department of Pediatrics, University of Pisa, Via Roma, 35, 56100 Pisa, Italy (Dr Saggese).
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